Background
Scenario analysis is a typical use case for infectious disease modelling - given what we think is going on, if we do X, how will it turn out compared to Y? Stochastic models are also a typical application - given a mix of uncertainty / chance whats going on, what’s the range of how things turn out?
When these two simulation activities are combined, there are some pitfalls. Those pitfalls are analogous (in a precise, not just illustrative) to the problems that can emerge in typical epidemiological studies. Briefly, they result from poor matching between control and treatment populations. This is addressable by fine control of the use of random numbers. However, such control can be quite complicated / computationally expensive, and its not always clear what level of control is appropriate.
Proposal
Some folks have been doing work on an approach to simplify the implementation of finer control, alongside highlighting how to think more clearly and explicitly about model choices and their implications. Currently at GitHub - pearsonca/hbmPRNG: Hash-based Matching Pseudo-Random Number Generation.
What do people think about pulling that approach implementation under the epinowcast banner?
I think its a nice solving-general-epi-modelling tool (pro), but its not really (at least yet) about real-time, “*casting” analyses (con).